Many have asked and wondered what it is I will be doing while I am here at Harvard. Well hopefully I can explain it a bit here and show you some fun (at least in my opinion) pictures.
I work with zebrafish (Danio rerio is the scientific name). An adult is shown below.
Zebrafish are an excellent tool for studying early development. Here is a quick video from YouTube that shows a time lapse of the first 24 hours after fertilization. The embryos I'll be working with are about 10-14 hours old. So about half way through this video, just when the eye begins to form.
More specifically I work with zebrafish embryos' eyes. I am hoping to understand the role Vitamin A plays in the zebrafish eye development. I use biochemical treatments to alter the Vitamin A production in 12 hour old embryos. I then look at the genes from the eyes at about 14 hours of age and compare untreated animals to treated animals using sophisticated gene microarrays. See below.
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The hope is to better understand the genes involved in early eye development associated with Vitamin A. Oh yeah, and did I mention that the fish I'll be working with fluoresce a yellow/green color in the presence of Vitamin A (RA)? (Photo published in Dev. Biol. 2001 229: 89-101)